Magnetic Resonance Imaging (MRI) based methods that allow collection of fat and water specific signals are considered the most accurate non-invasive assessments of liver fat. Ultrasonography (US) and Computed Tomography (CT) measure liver fat using indirect properties. Moreover, MRI and Magnetic Resonance Spectroscopy (MRS) can both be utilized. MRI uses a model of the water and lipid signal and allows coverage of the entire liver and high spatial resolution, while MRS provides high spectral resolution from a few voxels. The MRI-based methods with full liver coverage and high spatial resolution allow specific analysis of the liver parenchyma, which is of importance for precision as it avoids signals from large vessels and bile ducts. Total method precision using repeated imaging (test- retest) and analysis in ten healthy volunteers is 0.1 percentage points (mean of the ten standard deviations). Antaros Medical also quantifies liver volume in all studies to allow assessment of changes in the non-lipid component (e.g. glycogen) of the liver. This allows estimation of total liver fat content in addition to the liver fat concentration.
